Anti-AP2a [AP2a 8G8/5]

AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.

Contributors

Inventor Institute
Helen Hurst Queen Mary University of London
Cat. #: 151254
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics;Tissue-specific biology
Application: ChIP ; IHC ; WB
Target: Activating Protein 2 (AP-2) alpha (Human)
Reactivity: Human
Clone: AP2a 8G8/5
Host: Mouse
Class: Monoclonal
Product description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?Ÿ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 50 kDa
Immunogen: Bacterialy expressed AP-2a/AP-2g fusion protein.
Myeloma used: Sp2/0-Ag14
Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Format: Liquid
Concentration: 0.82 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Nordentoft et al. 2011. BMC Cancer. 11:135. PMID: 21489314.

Increased expression of transcription factor TFAP2a correlates with chemosensitivity in advanced bladder cancer.

Bennett et al. 2009. PLoS One. 4(9):e6931. PMID: 19742317.

AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma.

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