Cat. #151254
Anti-AP2a [AP2a 8G8/5]
Cat. #: 151254
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Activating Protein 2 (AP-2) alpha (Human)
Class: Monoclonal
Application: ChIP ; IHC ; WB
Reactivity: Human
Host: Mouse
£312.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Helen Hurst
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-AP2a [AP2a 8G8/5]
- Research fields: Cancer;Genetics;Tissue-specific biology
- Clone: AP2a 8G8/5
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 50 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ChIP ; IHC ; WB
- Description: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2?ĂÂ may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
- Immunogen: Bacterialy expressed AP-2a/AP-2g fusion protein.
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
- Recommended controls: Extract from breast cancer cell line ZR75-1
Target Details
- Target: Activating Protein 2 (AP-2) alpha (Human)
- Molecular weight: 50 kDa
- Tissue cell line specificity: Extract from breast cancer cell line ZR75-1
- Target background: AP-2 is a family of developmentally regulated transcription factors which also play a role in breast cancer and melanoma. AP-2? may be important in cardiac and kidney development. The AP-2 transcription factors form the OB2 complex that has been shown to up-regulate c-erb-B2 transcription.
Applications
- Application: ChIP ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.82 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Nordentoft et al. 2011. BMC Cancer. 11:135. PMID: 21489314.
- Increased expression of transcription factor TFAP2a correlates with chemosensitivity in advanced bladder cancer.
- Bennett et al. 2009. PLoS One. 4(9):e6931. PMID: 19742317.
- AP-2alpha induces epigenetic silencing of tumor suppressive genes and microsatellite instability in head and neck squamous cell carcinoma.
