Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5′ end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and […]
| Inventor | Institute |
|---|---|
| Walter Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151071 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | WB ; ELISA |
| Target: | Alkaline phosphatase |
| Reactivity: | Human |
| Clone: | AAP1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | D98/AH-2 (HeLa) cells, which produce human intestinal alkaline phosphatase ectopically |
| Myeloma used: | P3X63Ag8 |
| Target background: | Alkaline phosphatases are phosphodiesterases which remove phosphate groups from the 5' end of DNA, RNA and proteins at high pH. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. Detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Brock et al. 1985. Lancet. 1(8439):1175-8. PMID: 2860384. Prospective prenatal diagnosis of cystic fibrosis. Arklie et al. 1981. Tissue Antigens. 17(3):303-12. PMID: 7314066. A monoclonal antibody to intestinal alkaline phosphatase made against D98/AH-2 (HeLa) cells. |
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