![Western blot was performed on transfected 293T cell lysates using anti-AIF [3C11].](https://cancertools.org/wp-content/uploads/b6104a2f-9df1-4eaf-b63b-f31a6f936771.jpg "b6104a2f-9df1-4eaf-b63b-f31a6f936771.jpg")
Cat. #152633
Anti-AIF [3C11]
Cat. #: 152633
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Mammalian apoptosis-inducing factor
Class: Monoclonal
Application: WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: A*STAR Accelerate Technologies Pte Ltd
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-AIF [3C11]
- Research fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics;Metabolism
- Clone: 3C11
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: WB
- Description: Mammalian apoptosis-inducing factor (AIF) has been reported to be mainly found in the inter-membrane space of the mitochondria. After exposure to apoptotic stimuli, AIF is expelled as a soluble protein from the permeabilized mitochondria membrane and translocates to the nucleus, resulting in chromatin condensation and DNA cleavage. AIF mediated apoptosis is caspase-independent. AIF mutants that could not bind to DNA could not mediate cell death.
- Immunogen: AIF-His fusion protein
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: Mammalian apoptosis-inducing factor
- Target background: Mammalian apoptosis-inducing factor (AIF) has been reported to be mainly found in the inter-membrane space of the mitochondria. After exposure to apoptotic stimuli, AIF is expelled as a soluble protein from the permeabilized mitochondria membrane and translocates to the nucleus, resulting in chromatin condensation and DNA cleavage. AIF mediated apoptosis is caspase-independent. AIF mutants that could not bind to DNA could not mediate cell death.
Applications
- Application: WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
