Murine melanocyte cell line
| Inventor | Institute |
|---|---|
| Elena Sviderskaya | St. George's University London |
| SKU: | 162056 |
|---|---|
| Product description: | The melan-Gnas1, -Gnas2 and Gnas-3 cell lines are immortal melanocytes derived from Gnas-mutant Ink4aArf -/- C3H/C57BL/6J OlaHsd mice. The Gnas gene encodes the G?s protein, a subunit of the heterotrimeric G-protein complex that activates adenylate cyclase and increases cAMP production. Mutations in the human GNAS gene are found in pituitary tumours and result in constitutively activated G?s. Somatic gain-of-function mutations in GNAS are associated with McCune-Albright Syndrome, a rare disorder characterised by fibrous dysplasia of the bone, various endocrinopathies and hyperpigmented patches of skin. These murine melanocytes are hyperpigmented compared to littermate control lines. These melanocytes are a useful tool for studies of pigmentation genetics and for the effects of constitutively active cAMP signalling. Littermate control lines (melan-a9, -a10 and -a11) are also available from CancerTools.org. |
| Cat. #: | 162056 |
|---|---|
| Organism: | Mouse |
| Tissue: | Skin |
| Model: | Immortalised non-cancerous cell lines |
| Morphology: | Small, oval-fusiform |
| Primary citation: | Unpublished |
| Storage conditions: | liquid N2 |
|---|---|
| Shipping conditions: | Dry Ice |
| Growth medium: | RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM) |
| References: |
Unpublished |
|---|
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