Melan-le2 cell line

Immortal melanocyte cell lines derived from neonatal Hps4le/Hps4le C57BL/6J mice

Contributors

Inventor Institute
Elena Sviderskaya St. George's University London
Cat. #: 162013
Organism: Mouse
Tissue: Skin
Model: Immortalised non-cancerous cell lines
Morphology: Small, oval-fusiform
Product description: The melan-le1 and -le2 lines are immortal melanocyte cell lines derived from neonatal Hps4le/Hps4le C57BL/6J mice. These cell lines lack le (light ear), a subunit of the biogenesis of lysosome-related organelles complex 3 (BLOC-3). BLOC-3 is involved in cargo recycling from melanosomes. Pathogenic variants in the human ortholog of le, HPS4, cause a form of Hermansky-Pudlak syndrome (HPS), HPS type 4. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles.
disease: Hermansky-Pudlak syndrome
Storage conditions: liquid N2
Growth medium: RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM)

Related Tools for Cell lines

Cat. # Tool Name
151445 1-7HB2 Cell Line Key Info View Tool
151463 Omega-E Packaging Cell Line Key Info View Tool
151488 B6.1.1 Mouse ES Cell Line Key Info View Tool
151576 MEF RAF1 KO Cell Line Key Info View Tool
151665 MEF PKCe KO Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.