immortal melanocyte cell line derived from the skin of neonatal coa/coa Ink4aArf -/- C57BL/10J mice
| Inventor | Institute |
|---|---|
| Elena Sviderskaya | St. George's University London |
| SKU: | 162008 |
|---|---|
| Product description: | The melan-coa cell line is an immortal melanocyte cell line derived from the skin of neonatal coa/coa Ink4aArf -/- C57BL/10J mice. These cell lines lack HPS-3, a subunit of the biogenesis of lysosome-related organelles complex 2 (BLOC-2). The role of BLOC-2 is incompletely understood; however, it is involved in melanogenic cargo delivery to melanosomes. Pathogenic variants in the human ortholog of HPS3 cause a form of Hermansky-Pudlak syndrome (HPS), HPS type 3. HPS is a group of disorders characterised by hypopigmentation, bleeding tendency and other variable symptoms. These cells are mildly hypopigmented. These cells are a useful model for HPS and for the study of trafficking of cargoes towards lysosome-related organelles. |
| Disease: | Hermansky-Pudlak syndrome |
| Cat. #: | 162008 |
|---|---|
| Organism: | Mouse |
| Tissue: | Skin |
| Model: | Immortalised non-cancerous cell lines |
| Morphology: | Small, oval-fusiform |
| Primary citation: | Suzuki T, et al. Genomics. 2001 Nov;78(1-2):30-7. PMID: 11707070 |
| Storage conditions: | liquid N2 |
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| Shipping conditions: | Dry Ice |
| Growth medium: | RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM) |
| References: |
Suzuki T, et al. Genomics. 2001 Nov 78(1-2):30-7. PMID: 11707071 |
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