| Inventor | Institute |
|---|---|
| June L. Biedler | Memorial Sloan-Kettering Cancer Center (MSK) |
| SKU: | 161921 |
|---|---|
| Product description: | SK-N-BE(2) is a neuroblastoma cell line that displays MYCN amplification. These cells have moderate dopamine-b-hydroxylase activity and low-choline acetyltransferase activity. The SK-N-BE(2) cells are known to form tumours in immunocompromised mice. |
| Gender: | Male |
| Additional notes: | The cells exhibit moderate levels of dopamine beta hydroxylase activity. SK-N-BE(2) cells have a reported saturation density greater than 1 X 106 cells/cm2. The morphology of the cells varies with some cells having long processes and others that are epithelioid like. The cells will aggregate, form clumps and float. |
| Cellosaurus ID: | CVCL_0528 |
| Model description: | Tumourigenic; an inoculum of 107 cells produced tumours in cortisonised hamster cheek pouches with 18% frequency |
| Products or characteristics of interest: | Karyotype: modal number = 44; one or more HSR bearing chromosomes |
| Cat. #: | 161921 |
|---|---|
| Cancer types: | Neuroblastoma |
| Organism: | Human |
| Tissue: | Brain |
| Gender: | Male |
| Model: | Tumourigenic |
| Morphology: | Neuroblast |
| Growth properties: | Mixed: adherent and suspension |
| Cancer Types In Detail: | Neuroblastoma |
| Primary citation: | Biedler et al. 1976. Journal of the National Cancer Institute. 57: 683-695. PMID: 62055. |
| Storage conditions: | Vapor phase of liquid nitrogen |
|---|---|
| Shipping conditions: | Dry Ice |
| Growth medium: | 1:1 mixture of EMEM:F12 Medium, then supplemented with FBS to a final concentration of 10% |
| Temperature: | 37° C |
| Atmosphere: | 5% CO2 in air |
| Storage medium: | Complete growth medium supplemented with 5% (v/v) DMSO |
| Biosafety level: | 1 |
| References: |
Barnes et al. 1981. In Vitro. 17: 619-131. PMID: 7327593. Biedler et al. 1976. Science. 191: 185-187. PMID: 942798. Biedler et al. 1978. Cancer Research. 38: 3751-3757. PMID: 29704. |
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