Epithelial ovarian cancer cell lines spontaneously derived from high-grade serous solid tumors
| Inventor | Institute |
|---|---|
| Anne-Marie Mes-Masson and Diane Provencher | Centre Hospitalier de Luniversité de Montréal |
| SKU: | 161784 |
|---|---|
| Product description: | Epithelial ovarian cancer cell lines spontaneously derived from high-grade serous solid tumors. TOV3291G harbors a TP53 mutation, a comlex CNA pattern, and has a CDK12 mutation. |
| Alternate name: | TOV-3291G |
| Gender: | Female |
| CRISPR: | No |
| Production details: | Established using the Scrape method where tumor tissue was scraped into a 100mm plate with complete OSE medium and maintained for 40 days with medium replaced weekly. |
| Additional notes: | Patient 3291 was age 59 at diagnosis and BRCA hereditary status was negative. Their first line treatment was surgery followed by cisplatin/taxol. No previous personal history of cancer and yera of sampling was 2007. |
| Cellosaurus ID: | CVCL_9T25 |
| Receptors of note: | No |
| Cat. #: | 161784 |
|---|---|
| Cancer types: | Ovarian cancer |
| Research Fields: | Cancer |
| Organism: | Human |
| Tissue: | Derived from high-grade serous tumors |
| Gender: | Female |
| Morphology: | Formed loosely compact spheroids with irregular margins |
| Growth properties: | Adherent |
| Primary citation: | Fleury et al. 2015. Genes & Cancer. 6(9-10):378-398. PMID: 26622941 |
| Shipping conditions: | Dry Ice |
|---|---|
| Growth medium: | OSE medium contains 10% FBS, 0.5ug/mL amphotericin B and 50 ug/mL gentamicin |
| Atmosphere: | Low oxygen conditions of 7% O2 and 5% CO2 |
| References: |
Vias et al. 2023. Elife. 11 12:e83867. PMID: 37166279 Sevinyan et al. 2022. Cancers (Basel). 16 14(22):5628. PMID: 36428724 Asare-Werehene et al. 2023. Cancers (Basel). 30 15(9):2566. PMID: 37174032 |
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