detects CD109 antigen in several human pancreatic cancer cell lines and pancreatic cancer tissue array, with no expression in normal pancreatic tissues. It has a potential for use as diagnostic and therapeutic agent.
| Inventor | Institute |
|---|---|
| Helmout Modjtahedi | Kingston University |
| Cat. #: | 161582 |
|---|---|
| Tool sub type: | Primary antibody |
| Cancer types: | Pancreatic cancer |
| Research Fields: | Cancer |
| Application: | IHC, IF, IP, WB, ELISA, FACS |
| Target: | CD109 |
| Reactivity: | Human |
| Clone: | KU43.13A |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Arias-Pinilla et al. 2018. Oncotarget. 9(28): 19994ĂÂ20007. PMID: 29731998 |
| Product description: | KU43.13A mAb detects CD109 antigen with high level of expression in some of the human pancreatic cell lines (e.g. BxPC-3, PANC-1, FA-6 and MIA PaCa-2) |
|---|---|
| Isotype: | IgG2a |
| Molecular weight: | 170 KDa |
| Immunogen: | BxPC-3 cells |
| Target background: | CD109 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. It is highly expressed in cancers of various organs including the pancreas, lung, esophagus, uterine cervix, penis, and gallbladder, but hardly detectable in their normal tissues. |
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| Shipping conditions: | Dry ice |
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| References: |
Arias-Pinilla et al. 2018. Oncotarget. 9(28): 19994ĂÂ20007. PMID: 29731998 Arias-Pinilla et al. 2020. Sci Rep. 10(1):537. PMID: 31953437 |
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