Cat. #160643
Anti-ORF45 [8B8]
Cat. #: 160643
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Open Reading Frame 45 clone [8B8]
Class: Monoclonal
Application: IP
Reactivity: Other Species
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fanxiu Zhu
Institute: Florida State University Research Foundation
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ORF45 [8B8]
- Research fields: Genetics;Microbiology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Other Species
- Host: Mouse
- Application: IP
- Description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen. This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.
- Immunogen: A baculovirus-synthesized ORF45 was used as an antigen
- Isotype: IgG
Target Details
- Target: Open Reading Frame 45 clone [8B8]
- Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015).ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.
Applications
- Application: IP
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Dry ice
References
- Fu et al. 2015. J Virol. 89(1):195-207. PMID: 25320298.
