Anti-ALCAM AZN-L50 (IgG2A) [AZNL50]

ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation.

Contributors

Inventor Institute
Carl G. Figdor Radboud University Medical Center (UMC)
Cat. #: 159675
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Immunology
Application: FACS ; IP ; WB ; IP ; WB
Target: Activated leukocyte cell adhesion molecule
Reactivity: Human
Host: Mouse
Class: Monoclonal
Alternate name: CD166 antigen, MEMD
Product description: ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: K562-ALCAM
Immunogen Uniprot ID: Q13740
Target background: ALCAM, or CD166, is a cell adhesion molecule that mediates heterotypic cell-cell contacts via its interaction with CD6, resulting in initiation and stabilization of T-cell-dendritic-cell interactions affecting T-cell activation. It also engages in homotypic cell-cell contacts. These ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression.
Format: Liquid
Shipping conditions: Dry ice
References:

Te Riet et al. 2007. J Cell Sci. 120(Pt 22):3965-76. PMID: 17971418.

Images

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Surface expression of ALCAM on K562; K562-ALCAM; KG1a and undifferentiated MUTZ-3 cells was analyzed by flow cytometry. Unfilled histograms represent isotype control staining and shaded histograms represent staining with ALCAM antibody; AZN-L50. The mean fluorescence intensity (MFI) and percentage of positive cells are as indicated.

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