Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase).
| Inventor | Institute |
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| Richard Bennett | University of Florida Research Foundation |
| SKU: | 158410 |
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| Product description: | Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors. |
| Alternate name: | RAX/PACT; PRKRA |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to amino acids 13-25, including phosphorylated Serine 18, of mouse PACT protein |
| Cat. #: | 158410 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | ELISA ; WB ; IHC |
| Target: | Phosphorylated interferon-inducible double strane RNA-dependent protein kinease/Protein activator of the interferon-induced protein kinase (RAX/PACT) |
| Reactivity: | Human ; Rat ; Mouse |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Bennett et al. 2004. J Biol Chem. 279(41):42687-93. PMID: 15299031. |
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