MPO can generate several reactive oxidised intermediates, concomitantly inducing oxidative damage of cells and tissues (Brennan et al., 2003).
| Inventor | Institute |
|---|---|
| Barry McDonnell ; Caroline Murphy | Dublin City University |
| Cat. #: | 156520 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | ELISA ; WB |
| Target: | Myeloperoxidase |
| Host: | Chicken |
| Class: | Recombinant |
| Alternate name: | MPO |
|---|---|
| Product description: | MPO is a mediator enzyme secreted by inflammatory cells e.g. activated neutrophils and monocytes. MPO produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion (Cl-) (or the equivalent from a non-chlorine halide) during the neutrophil's respiratory burst, requiring heme as a cofactor. Furthermore, it oxidizes tyrosine to tyrosyl radical using hydrogen peroxide as an oxidizing agent (Heinecke et al., 1993). Both hypochlorous acid and tyrosyl radical are cytotoxic and a… |
| Conjugation: | Unconjugated |
| Immunogen: | Myeloperoxidase |
| Immunogen Uniprot ID: | TBC |
| Target background: | MPO is a mediator enzyme secreted by inflammatory cells e.g. activated neutrophils and monocytes. MPO produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride anion (Cl-) (or the equivalent from a non-chlorine halide) during the neutrophil's respiratory burst, requiring heme as a cofactor. Furthermore, it oxidizes tyrosine to tyrosyl radical using hydrogen peroxide as an oxidizing agent (Heinecke et al., 1993). Both hypochlorous acid and tyrosyl radical are cytotoxic and a… |
|---|
| Format: | Liquid |
|---|---|
| Storage buffer: | 1 x PBS |
| Storage conditions: | -20° C avoid repeated freeze and thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
McDonnell, Barry (2010) Development of novel antibody-based diagnostics for the early and rapid detection of cardiac markers. PhD thesis, Dublin City University. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151015 | Anti-CyclinA [E70.1] |
Key Info
Anti-CyclinA [E70.1]
|
View Tool | |||||||||||||||||||
| 151022 | Anti-IL12 [1-1A4] |
Key Info
Anti-IL12 [1-1A4]
|
View Tool | |||||||||||||||||||
| 151034 | Anti-HSVUL42 [13D11] |
Key Info
Anti-HSVUL42 [13D11]
|
View Tool | |||||||||||||||||||
| 151039 | Anti-Integrin aVb3 [23C6] |
Key Info
Anti-Integrin aVb3 [23C6]
|
View Tool | |||||||||||||||||||
| 151020 | Anti-CyclinB1 [V143.1] |
Key Info
Anti-CyclinB1 [V143.1]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.