Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines.
| Inventor | Institute |
|---|---|
| Andrew Hollenbach | Louisiana University Health Sciences Center New Orleans (LSU) |
| SKU: | 156473 |
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| Product description: | Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines. |
| Conjugation: | Unconjugated |
| Immunogen: | synthetic peptide: NH2-DID(pS)EPDLPLKRC-CO2 |
| Cat. #: | 156473 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Developmental biology |
| Application: | WB |
| Target: | Phosphorylated Ser209 of Pax3 |
| Reactivity: | Human ; Mouse |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947. Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083. |
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