R-3327-MAT-Lu cell line

This cell line was derived from the “H” subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The “H” subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells

Contributors

Inventor Institute
John Isaacs Johns Hopkins University
Cat. #: 156409
Unit size: 1×10^6 cells / vial
Cancer types: Prostate cancer
Research Fields: Cancer;Drug development
Model: Cancer Model
Cancer Types In Detail: Prostate
Product description: This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this AT-1 sublinein intactmale rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lung (MAT-Lu). This cell line is a valuable model for the studying prostate malignancies both in vitro, and in vivo.DM 3852
Cellosaurus ID: CVCL_3847
Disease: Cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Isaacs et al. 1988. Prostate. 13(2):165-88. PMID: 3174494.

Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.

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