Monoclonal antibody which binds an epitope within the CD3-TCR complex.
| Institute |
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| Yale University |
| SKU: | 155234 |
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| Product description: | Monoclonal antibody which binds an epitope within the CD3-TCR complex. Background and Research Application The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3γ, CD3δ and 2X CD3Ɛ), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex. |
| Conjugation: | Unconjugated |
| Immunogen: | P07766 |
| Immunogen Uniprot ID: | P07766 |
| Cat. #: | 155234 |
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| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Target: | CD3 |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | Monoclonal antibody which binds an epitope within the CD3-TCR complex. Background and Research Application The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3γ, CD3δ and 2X CD3Ɛ), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176. Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436. Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202. Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817. |
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