CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154800 |
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| Product description: | CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-ÄÂ?B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
| Alternate name: | Tumor Necrosis Factor Receptor Superfamily, Member 7; TNFRSF7 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 60 kDa |
| Immunogen: | Armenian hamster fibroblasts transfected with the mouse CD27 DNA. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154800 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy; Cell signaling and signal transduction; Immunology |
| Application: | ELISA ; FACS ; IHC ; IP |
| Target: | CD27 |
| Reactivity: | Human ; Mouse |
| Host: | Hamster |
| Class: | Monoclonal |
| Target background: | CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Hendriks et al. 2000. Nat Immunol. 1(5):433-40. PMID: 11062504. Gravestein et al. 1996. J Exp Med. 184(2):675-85. PMID: 8760821. Gravestein et al. 1995. Int Immunol. 7(4):551-7. PMID: 7547681. |
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