Cat. #154771
Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1]
Cat. #: 154771
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD11b/CR3
Class: Monoclonal
Application: FACS ; IP
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Netherlands Cancer Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD11b/CR3 (Integrin Subunit Alpha M) [BEAR1]
- Alternate name: ITGAM; Leukocyte Adhesion Receptor MO1
- Research fields: Cell biology;Cell signaling and signal transduction;Immunology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 160 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IP
- Description: ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (ÄÂ?MÄÂ?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of ÄÂ?MÄÂ?2 is the common integrin ÄÂ?2 subunit known as CD18, and integrin ÄÂ?MÄÂ?2 thus belongs to the ÄÂ?2 subfamily (or leukocyte) integrins. ÄÂ?MÄÂ?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
- Immunogen: The mouse was immunized with purified human monocytes
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: CD11b/CR3
- Molecular weight: 160 kDa
- Target background: ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (aM?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of aM?2 is the common integrin ?2 subunit known as CD18, and integrin aM?2 thus belongs to the ?2 subfamily (or leukocyte) integrins. aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
Applications
- Application: FACS ; IP
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.
