aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
| Institute |
|---|
| Netherlands Cancer Institute |
| SKU: | 154771 |
|---|---|
| Product description: | ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (ÄÂ?MÄÂ?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of ÄÂ?MÄÂ?2 is the common integrin ÄÂ?2 subunit known as CD18, and integrin ÄÂ?MÄÂ?2 thus belongs to the ÄÂ?2 subfamily (or leukocyte) integrins. ÄÂ?MÄÂ?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation |
| Alternate name: | ITGAM; Leukocyte Adhesion Receptor MO1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 160 kDa |
| Immunogen: | The mouse was immunized with purified human monocytes |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154771 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IP |
| Target: | CD11b/CR3 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (aM?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of aM?2 is the common integrin ?2 subunit known as CD18, and integrin aM?2 thus belongs to the ?2 subfamily (or leukocyte) integrins. aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266. |
|---|
| Cat. # | Tool Name | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151031 | Anti-RuvA [RuvA 12C6] |
Key Info
Anti-RuvA [RuvA 12C6]
|
View Tool | |||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||
| 151036 | Anti-ICAM1 [15.2] |
Key Info
Anti-ICAM1 [15.2]
|
View Tool | |||||||||||||||
| 151038 | Anti-Cytochrome P450 4A2, 4A3 [Clo4] |
Key Info
Anti-Cytochrome P450 4A2, 4A3 [Clo4]
|
View Tool | |||||||||||||||
| 151040 | Anti-Integrins aL, aX, aMb2 [24] |
Key Info
Anti-Integrins aL, aX, aMb2 [24]
|
View Tool | |||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.