Mouse model with conditional AEG-1 knockout in hepatocytes
| Inventor | Institute |
|---|---|
| Devanand Sarkar | Virginia Commonwealth University |
| SKU: | 154270 |
|---|---|
| Product description: | Mouse model with conditional AEG-1 knockout in hepatocytes |
| Conditional: | Yes |
| Conditional description: | Conditional AEG-1ÎHEP knockout after single i.p. injection of 10Âľg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water. |
| Production details: | Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with Alb/Cre (B6.Cg-Tg(Alb-cre)21Mgn/J) |
| Cat. #: | 154270 |
|---|---|
| Research Fields: | Cancer;Cell signaling and signal transduction;Genetics;Immunology |
| Target: | Astrocyte Elevated Gene-1 |
| Disease: | Hepatocellular Carcinogenesis |
| Model: | Conditional KO |
| Zygosity: | unknown |
| Strain: | C57BL/6 |
| Phenotype: | Hepatocellular Carcinogenesis |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179. Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. |
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