Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans double KO mouse

Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice

Contributors

Inventor Institute
Lijun Xia Oklahoma Medical Research Foundation
Cat. #: 154266
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
Target: Core 3- intestinal derived O-glycans and core 1- intestinal derived O-glycans
disease: Spontaneous Colitis-Associated Cancer
Model: Knock-Out
Zygosity: unknown
Strain: C57BL/6
Phenotype: Spontaneous colitis-associated colon cancer
Product description: Defective intestinal mucin-type O-glycosylation causes colonic mucus barrier breach and subsequent microbiota-mediated activation of caspase1-dependent inflammasomes in colonic epithelial cells which cause spontaneous colitis-associated cancer in mice
Conditional: No
Genetic background: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
Production details: Mice were generated by crossing core-3 intestinal derived O-glycans with core-1 intestinal derived O-glycans
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Bergstrom et al. 2016. Gastroenterology. 151(1):152-164.e11. PMID: 27059389.

Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice.

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