| Institute |
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| Hudson Institute Of Medical Research |
| SKU: | 154232 |
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| Product description: | Potential marker for preeclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia |
| Alternate name: | HtrA3, High-temperature requirement factor A3,Pregnancy-related serine protease |
| Conjugation: | Unconjugated |
| Molecular weight: | 48 kDa (46.9 kDa plus 1 kDa for the His tag) |
| Immunogen: | HtrA3-L-S305A protein |
| Immunogen Uniprot ID: | P83110, HTRA3_HUMAN |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154232 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Tissue-specific biology |
| Application: | IHC ; WB |
| Target: | Long isoform Human HtrA3 (high temperature requirement factor A) |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Potential marker for preeclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Wang et al. 2018. SLAS Discov. 23(10):1092-1099. PMID: 27932697. HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia. Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities. Singh et al. 2014. PLoS One. 9(9):e108235. PMID: 25248123. HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening. Dynon et al. 2012. PLoS One. 7(9):e45956. PMID: 23049902. |
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