Anti-phospho Sam68, Ser113/117

Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis.

Contributors

Inventor Institute
Fengyi Wan Johns Hopkins University
SKU: 153988
Product description: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-Î?B) compl…
Alternate name: KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68
Conjugation: Unconjugated
Molecular weight: 68 kDa
Immunogen: Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH)
Cat. #: 153988
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Ovarian cancer
Research Fields: Apoptosis and autophagy; Cell biology; Cell signaling and signal transduction; Genetics
Application: IHC ; WB
Target: Sam68(Src-associatedduringmitosis,68 kDa)
Reactivity: Human ; Mouse ; Rat
Host: Rabbit
Class: Polyclonal
Target background: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-B) co…
Format: Liquid
Shipping conditions: Dry ice
References:

Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.

Sam68 modulates the promoter specificity of NF-B and mediates expression of CD25 in activated T cells.

Images

View Gallery

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.