Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis.
| Inventor | Institute |
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| Fengyi Wan | Johns Hopkins University |
| Cat. #: | 153988 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Gynaecologic cancer |
| Research Fields: | Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Genetics |
| Application: | IHC ; WB |
| Target: | Sam68(Src-associatedduringmitosis,68 kDa) |
| Reactivity: | Human ; Mouse ; Rat |
| Host: | Rabbit |
| Class: | Polyclonal |
| Alternate name: | KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68 |
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| Product description: | Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-ÄÂ?B) compl… |
| Conjugation: | Unconjugated |
| Molecular weight: | 68 kDa |
| Immunogen: | Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH) |
| Target background: | Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-B) co… |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268. Sam68 modulates the promoter specificity of NF-B and mediates expression of CD25 in activated T cells. |
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