Anti-phospho Sam68, Ser113/117

Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis.

Contributors

Inventor Institute
Fengyi Wan Johns Hopkins University
Cat. #: 153988
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Ovarian cancer
Research Fields: Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Genetics
Application: IHC ; WB
Target: Sam68(Src-associatedduringmitosis,68 kDa)
Reactivity: Human ; Mouse ; Rat
Host: Rabbit
Class: Polyclonal
Alternate name: KH domain-containing, RNA-binding, signal transduction-associated protein 1, GAP-associated tyrosine phosphoprotein p62, Src-associated in mitosis 68 kDa protein, p21 Ras GTPase-activating protein-associated p62, p68
Product description: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-Î?B) compl…
Conjugation: Unconjugated
Molecular weight: 68 kDa
Immunogen: Synthetic peptide (NH2-CAEKD(Sp)LDP(Sp)FTH-COOH)
Target background: Sam68 (KHDRBS1 also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1) is a RNA binding protein that binds to U(U/A)AA direct repeats to regulate RNA splicing, transcription, RNA metabolism, signal transduction, the cell cycle and apoptosis. Post-translational modifications on Sam68 is what allows it to regulate many different cellular process. For instance, when Sam68 is phosphorylated, on serine 113 and 117, it forms nuclear factor-kappaB (NF-B) co…
Format: Liquid
Shipping conditions: Dry ice
References:

Fu et al. 2013. Nat Commun. 4:1909. PMID: 23715268.

Sam68 modulates the promoter specificity of NF-B and mediates expression of CD25 in activated T cells.

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