Anti-p53 [DO-13]

Mouse anti human p53 antibody, clone DO-13 recognizes the human cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13.

Contributors

Inventor Institute
David Lane University of Dundee
SKU: 153404
Product description: Mouse anti-human p53 antibody, clone DO-13 recognises the human cellular tumour antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein upregulated in response to DNA damage and is found in a wide variety of transformed cells. DO-13 binds to an epitope between amino acids 26-35.
Alternate name: p53
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 53 kDa
Immunogen: Recombinant human p53
Cat. #: 153404
Provenance and Ownership: The Anti-p53 [DO-13] is owned by Cancer Research UK. CancerTools supplies the Anti-p53 [DO-13] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-p53 [DO-13] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Other
Research Fields: Apoptosis and autophagy; Cancer; Cell biology; Immunology
Application: IHC ; IP ; WB
Target: Human TP53 / p53
Reactivity: Human
Clone: DO-13
Host: Mouse
Class: Monoclonal
Target background: p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the “guardian of the genome,” p53 prevents gene mutations. Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of fun…
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Hsieh et al. 2002. Mol Cell Biol. 22(1):78-93. PMID: 11739724.

Vojtesek et al. 1995. Oncogene. 10(2):389-93. PMID: 7530828.

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