![Immunohistochemistry images are showing a strong cytoplasmic positivity of ELOVL5 in (A) primary colorectal cancer whilst weak staining is observed in (B) normal colon mucosa using Anti-ELOVL5 [Z88]. IHC was performed on formalin-fixed; paraffin-embedded tissue sections. Antigen retrieval step is required (microwave 10 min @ 950W in 0.01M sodium citrate buffer; pH 6.0).](https://cancertools.org/wp-content/uploads/338cb92b-ef4a-401d-beb7-23fe2b6acc6f.png)
Cat. #153343
Anti-ELOVL5 [Z88]
Cat. #: 153343
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: ELOVL Fatty Acid Elongase 5
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-ELOVL5 [Z88]
- Alternate name: Elongation of very long chain fatty acids protein 5; ELOVL5; 3-keto acyl-CoA synthase ELOVL5; ELOVL FA elongase 5; Fatty acid elongase 1; Very long chain 3-ketoacyl-CoA synthase 5
- Research fields: Cell signaling and signal transduction;Tissue-specific biology
- Clone: Z88
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: This protein is involved in the elongation of long-chain polyunsaturated fatty acids functioning as a condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. It may also participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum.
- Immunogen: Peptide Sequence NNVKPRKLR (peptide immunogen is identical in primates)
- Isotype: IgG
- Myeloma used: P3X63Ag8.653
- Recommended controls: Western Blot: Jurkat cell lysates. IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray.
Target Details
- Target: ELOVL Fatty Acid Elongase 5
- Tissue cell line specificity: Western Blot: Jurkat cell lysates. IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray.
- Target background: This protein is involved in the elongation of long-chain polyunsaturated fatty acids functioning as a condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. It may also participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.
- The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis. Alnabulsi et al. 2019. Int J Cancer. :. PMID: 30737786.
