Anti-Phospho Endosulfine [CX2.1]

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase.

Contributors

Inventor Institute
Julian Gannon Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 153179
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Neurobiology
Application: WB
Target: Phospho Endosulfine
Reactivity: Xenopus laevis
Clone: CX2.1
Host: Mouse
Class: Monoclonal
Product description: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.Endosulfine is highly phosphorylated in Xenopus CSF egg extracts but de-phosphorylated when the eggs enter interphase.
Conjugation: Unconjugated
Molecular weight: 14 kDa
Immunogen: Synthetic peptide – KGQKYFD-Sp-GDYNMAK
Target background: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.Endosulfine is highly phosphorylated in Xenopus CSF egg extracts but de-phosphorylated when the eggs enter interphase.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

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