The antibody, NCRC37, is a pan-reactive, anti-colorectal tumour antibody and binds strongly to coloretal tumour cells and to post mortem cryopreserved tissues of brain, spleen, heat, lung, kidney, testes, oesophagus or stomach.
| Inventor | Institute |
|---|---|
| Lindy Durrant | University of Nottingham |
| SKU: | 152939 |
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| Product description: | Blood group related antigens are a group of carbohydrate determinants present on both glycoproteins and glycolipids. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Lewis- y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be over-expressed on breast, lung, colon and ovarian cancer cells. Lewis-y antigen, a difucosylatedtetrasaccharide, is found on type 2 blood group oligosaccharides. The antibody, NCRC37, is a pan-reactive, anti-colorectal tumour antibody and binds strongly to coloretal tumour cells and to post mortem cryopreserved tissues of brain, spleen, heat, lung, kidney, testes, oesophagus or stomach. Lewis y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Tissue cultured colorectal tumor cell lines (C170, C146, Colo205, and JW) |
| Myeloma used: | NS0 |
| Cat. #: | 152939 |
|---|---|
| Provenance and Ownership: | The Anti-Lewis y/b hapten [NCRC37] is owned by Cancer Research UK. CancerTools supplies the Anti-Lewis y/b hapten [NCRC37] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Lewis y/b hapten [NCRC37] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | ELISA ; FACS ; IHC ; Fn |
| Target: | Sialyltetraosylceramiden antigen on colorectal tumor cell surface |
| Reactivity: | Human |
| Clone: | NCRC37 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Blood group related antigens are a group of carbohydrate determinants present on both glycoproteins and glycolipids. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Lewis- y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be over-expressed on breast, lung, colon and ovarian cancer cells. Lewis-y antigen, a difucosylatedtetrasaccharide, is found on type 2 blood group oligosaccharides. The antibody, NCRC37, is a pan-reactive, anti-colorectal tumour antibody and binds strongly to coloretal tumour cells and to post mortem cryopreserved tissues of brain, spleen, heat, lung, kidney, testes, oesophagus or stomach. Lewis y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer. |
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| Format: | Liquid |
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| Concentration: | 1.14 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Durrant et al. 2006. Cancer Res. 66(11):5901-9. PMID: 16740730. A new anticancer glycolipid monoclonal antibody, SC104, which directly induces tumor cell apoptosis. Durrant et al. 1993. Hybridoma. 12(6):647-60. PMID: 7507082. Development of second generation monoclonal antibodies recognising Lewisy/b antigen by anti-idiotypic immunisation. |
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