Anti-CD11b [2LPM19c]

CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies.

Contributors

Inventor Institute
Karen Pulford University of Oxford
Cat. #: 152935
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Immunology;Neurobiology;Stem cell biology
Application: FACS ; IHC
Target: Cluster of Differentiation 11b (CD11b)
Reactivity: Human
Clone: 2LPM19c
Host: Mouse
Class: Monoclonal
Alternate name: CD11b, Integrin alpha M, Integrin aM, Mac-1 a subunit, C3bi receptor, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
Product description: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, M?Ÿ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 127 kDa
Immunogen: Purified C3bi receptor
Myeloma used: P3/NS1/1-Ag4.1
Target background: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, M?2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.

c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.

Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.

Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.

Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

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