Mapt-9A18 phosphodefective Tau Mouse

Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer’s disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding […]

Contributors

Inventor Institute
Michael Coleman Babraham Institute
Cat. #: 152794
Research Fields: Cell biology;Genetics;Neurobiology
Target: Microtubule-associated protein Tau
disease: Dementia
Model: Knock-In
Strain: C57BL/6
Alternate name: MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
Product description: Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a matched counterpart mouse model for the Mapt9E18 phosphomimetic tau knockin mouse which has 18 glutamate substitutions as a model of an inherited taupathy; frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T).
Conditional: No
References:

Gilley J et al. Neurobiol Aging. 2016 Mar

39:1-18

PMID: 26923397

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