E3 Cell Line
Exclusive toolThe E3 cell line was developed to examine the possibility of using the MUC1 gene and its products in active immunization against breast and other carcinomas.
Contributors
| Inventor | Institute |
|---|---|
| Joyce Taylor-Papadimitriou ; Joy Burchell | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 152597 |
|---|---|
| Product description: | The E3 cell line was developed to examine the possibility of using the MUC1 gene and its products in active immunization against breast and other carcinomas. |
| Gender: | Male |
| CRISPR: | Yes |
| Conditional: | Yes |
| Production details: | The E3 cell line was developed from the 410.4 murine mammary cell line by transfection of the hygromycin resistance gene with the MUC1 gene. |
| Cellosaurus ID: | CVCL_W345 |
| Parental cell line: | 410.4 |
| Disease: | Cancer |
| Cat. #: | 152597 |
|---|---|
| Provenance and Ownership: | The E3 Cell Line is owned by Cancer Research UK. CancerTools supplies the E3 Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing E3 Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Continuous |
| Unit size: | 1×10^6 cells / vial |
| Cancer types: | Breast cancer |
| Organism: | Mouse |
| Tissue: | Breast |
| Gender: | Male |
| Model: | Immortalised Line |
| Format: | Frozen |
|---|---|
| Shipping conditions: | Dry ice |
| Growth medium: | DMEM, 10S , 400??g/ml hygromycin |
| Mycoplasma free: | Yes |
| References: |
Julien et al. 2009. Br J Cancer. 100(11):1746-54. PMID: 19436292. Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model. Smith et al. 1999. Immunology. 97(4):648-55. PMID: 10457219. Expression of B7.1 in a MUC1-expressing mouse mammary epithelial tumour cell line inhibits tumorigenicity but does not induce autoimmunity in MUC1 transgenic mice. Lalani et al. 1991. J Biol Chem. 266(23):15420-6. PMID: 1714457. Expression of the gene coding for a human… |
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