Cat. #151903
Anti-Keratin K1 [LHK1]
Cat. #: 151903
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Keratin 1
Class: Monoclonal
Application: IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Nick Tidman
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Keratin K1 [LHK1]
- Research fields: Cell signaling and signal transduction
- Clone: LHK1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 68 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC ; WB
- Description: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.
- Immunogen: 13-amino acid (1 .75-kd) sequence (VRFVSTSYSGVTR) of the K1 polypeptide C terminus
- Isotype: IgG2a kappa
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: Keratin 1
- Molecular weight: 68 kDa
- Target background: Reactivity on normal human skin sections is suprabasal up to the tratum corneum in interfollicular epidermis. The suprabasal in the upper outer root sheath are also reactive. Very good marker for suprabasal keratinocytes.
Applications
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Bloor et al. 2003. Am J Pathol. 162(3):963-75. PMID: 12598329.
- Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.
- Waseem et al. 1999. J Invest Dermatol. 112(3):362-9. PMID: 10084315.
- Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes.
- Machesney et al. 1998. Am J Pathol. 152(5):1133-41. PMID: 9588880.
- Activated keratinocytes in the epidermis of hypertrophic scars.
- Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.
- Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.
