Anti-MCM5 [A2.4B4.B7.A11.A8]

It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal.

Contributors

Inventor Institute
Ron Laskey University of Cambridge
Cat. #: 151727
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics
Application: IF ; WB
Target: Mini Chromosome Maintenance protein5 (MCM5)
Reactivity: Human
Clone: A2.4B4.B7.A11.A8
Host: Mouse
Class: Monoclonal
Alternate name: Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12
Product description: MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal.
Conjugation: Unconjugated
Isotype: IgG2b
Immunogen: Bacterially expressed His-tagged human Mcm5 (amino acids 367-582)
Myeloma used: Sp2/0-Ag14
Target background: MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Stoeber et al. 2002. J Natl Cancer Inst. 94(14):1071-9. PMID: 12122098.

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.

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