Anti-ATG13 [ATG13]

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Autophagy has been implicated in a number of medical contexts, such as cancer, neurodegeneration, and immunity.

Contributors

Inventor Institute
Sharon Tooze Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151612
Product description: Atg13 only binds in the unphosphorylated state, and its dephosphorylation has been shown to be TOR dependent.
Conjugation: Unconjugated
Immunogen: C-terminal synthetic peptide
Cat. #: 151612
Provenance and Ownership: The Anti-ATG13 [ATG13] is owned by Cancer Research UK. CancerTools supplies the Anti-ATG13 [ATG13] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-ATG13 [ATG13] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy; Cancer; Cell signaling and signal transduction; Metabolism
Application: WB
Target: ATG13
Reactivity: Human
Clone: ATG13
Host: Rabbit
Class: Polyclonal
Target background: Autophagy has been implicated in a number of medical contexts, such as cancer, neurodegeneration, and immunity. The serine-threonine protein kinase Atg1 was originally identified as a critical autophagy regulator in yeast. Full kinase activity of Atg1 in yeast requires its binding partners Atg13 and Atg17.
Format: Liquid
Shipping conditions: Dry ice
References:

Chan et al. 2009. Mol Cell Biol. 29(1):157-71. PMID: 18936157.

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

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