Anti-SIGLEC5 [1A5]

The Siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Siglec5 (CD170) is a member of the recently-described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33- related siglecs, […]

Contributors

Inventor Institute
Paul Crocker University of Dundee
Cat. #: 151589
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Immunology
Application: IHC ; ELISA ; FACS ; IHC ; IF ; IP ; Fn ; WB
Target: Siglec5
Reactivity: Human
Clone: 1A5
Host: Mouse
Class: Monoclonal
Alternate name: Sialic Acid Binding Ig Like Lectin 5; Obesity-Binding Protein 2; OB-Binding Protein 2; CD33 Antigen-Like 2; SIGLEC-5; CD33L2; OBBP2; Sialic Acid-Binding Immunoglobulin-Like Lectin 5; CD17 Antigen;
Product description: The Siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Siglec5 (CD170) is a member of the recently-described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33- related siglecs, Siglec-5 contains two tyrosine based motifs in its cytoplasmic tails implicated in signalling functions. The antibody cross reacts with Siglec14.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Siglec-5-Fc protein, containing entire extracellular region of siglec-5 fused with the Fc region of human IgG1
Myeloma used: Sp2/0-Ag14
Target background: The Siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Siglec5 (CD170) is a member of the recently-described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33- related siglecs, Siglec-5 contains two tyrosine based motifs in its cytoplasmic tails implicated in signalling functions. The antibody cross reacts with Siglec14.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Angata et al. 2006. FASEB J. 20(12):1964-73. PMID: 17012248.

Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.

Nguyen et al. 2006. Proc Natl Acad Sci U S A. 103(20):7765-70. PMID: 16682635.

Loss of Siglec expression on T lymphocytes during human evolution.

Avril et al. 2005. J Biol Chem. 280(20):19843-51. PMID: 15769739.

Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.

Connolly et al. 2002. Br J Haematol. 119(1):221-38. PMID: 12358929

Human Siglec-5: tissue distribution, novel isoforms and domain specificities for sialic acid-dependent ligand interactions.

Cornish et al. 1998. Blood. 92(6):2123-32. PMID: 9731071.

Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.

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