K14dNb Mouse

In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;

Contributors

Inventor Institute
Fiona Watt Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151565
Cancer types: Digestive / Gastrointestinal cancer;Skin cancer
Research Fields: Cancer;Cell signaling and signal transduction;Genetics;Neurobiology;Stem cell biology;Tissue-specific biology
Target: Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER)
disease: Cancer
Model: Knock-Out
Phenotype: Skin abnormalities (hair follicle);
Product description: In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
Conditional: Yes
Conditional description: Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression.
Genetic background: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Production details: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Shipping conditions: Embryo/Spermatoza- Dry Ice

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