| Institute |
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| University of Birmingham |
| SKU: | 151490 |
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| Product description: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). |
| Alternate name: | Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2 |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151490 |
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| Unit size: | 100 ug |
| Research Fields: | Cell biology; Immunology; Stem cell biology; Tissue-specific biology |
| Application: | FACS ; IHC ; IP |
| Target: | ICAM1 (CD54) |
| Reactivity: | Human |
| Clone: | BU74 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Baker et al. 1998. Blood. 92(8):2830-43. PMID: 9763568. Prolonged phenotypic, Fn, and molecular change in group I Burkitt lymphoma cells on short-term exposure to CD40 ligand. |
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