Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. Integrin alpha II combines with Integrin beta 1 to form the alpha2/beta1 integrin duplex. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
| Inventor | Institute |
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| Fiona Watt | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151485 |
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| Product description: | Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. Integrin alpha II combines with Integrin beta 1 to form the alpha2/beta1 integrin duplex. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151485 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Cell signaling and signal transduction; Metabolism |
| Application: | FACS ; IHC ; IP |
| Target: | Integrin alpha 2 subunit (CD49b) |
| Clone: | HAS-6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. Integrin alpha II combines with Integrin beta 1 to form the alpha2/beta1 integrin duplex. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sugiyama et al. 1993. Carcinogenesis. 14(10):2171-6. PMID: 7693359. Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas. Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749. Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes. |
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