Anti-FCER2 [BU38]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-FCER2 [BU38]
• Alternate name: Fc Fragment Of IgE Receptor II; Immunoglobulin E-Binding Factor; Lymphocyte IgE Receptor; Fc Epsilon Receptor II; CD23 Antigen; BLAST-2; CLEC4J; IGEBF; FCE2; C-Type Lectin Domain Family 4; Member; Immunoglobulin Epsilon-Chain; CD23
• Research fields: Immunology;Stem cell biology
• Clone: BU38
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; IF ; IP ; WB
• Description: Fc epsilon RII (CD23), a low-affinity IgE receptor, is widely expressed on the surface of a number of cell types. Fc epsilon RII mediates numerous IgE-related immune responses. Both membrane and soluble Fc epsilon RII play important roles in allergic responses.
• Immunogen: Full length native CD23 of human origin
• Isotype: IgG1
• Myeloma used: NS0
• Recommended controls: Follicular lymphoma or tonsil (mantle cell lymphomas are negative)

Target Details

• Target: Fc epsilon RII (FCER2, CD23)
• Tissue cell line specificity: Follicular lymphoma or tonsil (mantle cell lymphomas are negative)
• Target background: Fc epsilon RII (CD23), a low-affinity IgE receptor, is widely expressed on the surface of a number of cell types. Fc epsilon RII mediates numerous IgE-related immune responses. Both membrane and soluble Fc epsilon RII play important roles in allergic responses.

Applications

• Application: FACS ; IHC ; IF ; IP ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Aubry JP. et al. 1987. Leucocyte Typing III. Oxford University Press-Oxford, New York, Tokyo
• Knapp W. et al. 1989. Leukocyte Typing IV. Oxford University Press
• Leucocyte Typing VI, Garland Publishing (1998)
• Schlossman S.F. et al. 1995. Leukocyte Typing V. Oxford University Press
• Maeda et al. 2002. J Histochem Cytochem. 50(11):1475-86. PMID: 12417613.
• Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections.
• Karagiannis et al. 2001. Immunology. 103(3):319-31. PMID: 11454061.
• Endocytosis and recycling of the complex between CD23 and HLA-DR in human B cells.
• Sancho et al. 2000. J Immunol. 165(7):3868-75. PMID: 11034393.
• Fn analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors.
• Chen et al. 2000. Appl Immunohistochem Mol Morphol. 8(1):1-11. PMID: 10937042.
• Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel.
• Sano et al. 1999. Proc Assoc Am Physicians. 111(1):82-91. PMID: 9893160.
• Upregulated surface expression of intracellularly sequestered Igepsilon receptors (FcepsilonRII/CD23) following activation in human peripheral blood eosinophils.
• Kroft et al. 1998. Mod Pathol. 11(10):967-70. PMID: 9796724.
• Evaluation of CD23 expression in paraffin-embedded gastric lymphomas of mucosa-associated lymphoid tissue.
• Sarsfield et al. 1996. J Pathol. 180(1):18-25. PMID: 8943810.
• Kumar et al. 1996. Mod Pathol. 9(9):925-9. PMID: 8878025.
• Use of CD23 (BU38) on paraffin sections in the diagnosis of small lymphocytic lymphoma and mantle cell lymphoma.
• A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis.
• Bonnefoy et al. 1995. Curr Opin Immunol. 7(3):355-9. PMID: 7546400.
• CD23 and B-cell activation.
• Hardie et al. 1993. Eur J Immunol. 23(5):997-1004. PMID: 8477815.
• Quantitative analysis of molecules which distinguish Fn compartments within germinal centers.
• Murray et al. 1991. J Pathol. 165(2):125-8. PMID: 1744798.
• CD23 expression in non-Hodgkin lymphoma: immunohistochemical demonstration using the antibody BU38 on paraffin sections.
• Hellen et al. 1991. J Clin Pathol. 44(4):293-6. PMID: 1827636.
• Immunohistochemical demonstration of CD23 expression on lymphocytes in rheumatoid synovitis.
• Rowlands et al. 1990. J Pathol. 160(3):239-43. PMID: 2139890.
• Immunohistochemical determination of CD23 expression in Hodgkin's disease using paraffin sections.