CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin.
| Inventor | Institute |
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| Karen Pulford | University of Oxford |
| SKU: | 151341 |
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| Product description: | T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin. |
| Alternate name: | CD2 Molecule; CD2 Antigen (P5); Sheep Red Blood Cell Receptor; T-Cell Surface Antigen T11/Leu-5; Erythrocyte Receptor; Rosette Receptor; LFA-3 Receptor |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | T cell lymphoma cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151341 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer; Cell biology; Immunology; Stem cell biology |
| Application: | FACS ; IHC |
| Target: | CD2 |
| Reactivity: | Human |
| Clone: | X53 (X/3) |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
CD guide for CD2 (1989) Leukocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo p1074-1075 Pawelec G et al. 1989. Stimulatory capacity of Workship T-cell antibodies on T-lymphocyte clones. Leukocyte Typing IV, Oxford Univeristy Press, Oxford, New York and Tokyo p310-311.2. |
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