Anti-ASF1 [ASF 4A1/3]

ASF1 A and B (the two human subtypes) are the only known substrate for Tousled-like kinase (TLK). The Tousled kinases are themselves regulated by the checkpoint protein kinases involved in the DNA damage response.

Contributors

Institute
Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151319
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics
Application: WB
Target: Anti-Silencing Function 1 (ASF1)
Reactivity: Human ; Mouse
Clone: ASF 4A1/3
Host: Mouse
Class: Monoclonal
Product description: Anti-silencing function 1 (Asf1) belongs to the H3/H4 family of histone chaperones. Its function has not been fully elucidated but it is believed to be involved in ensuring a constant supply of histones at sites of nucleosome assembly. Asf1 interacts with the DNA damage checkpoint protein Rad53 and so may have a role in cell cycle regulation and DNA responses. ASF1 A and B (the two human subtypes) are the only known substrate for Tousled-like kinase (TLK). The Tousled kinases are themselves regulated by the checkpoint protein kinases involved in the DNA damage response.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: FLAG-ASF1A
Myeloma used: Sp2/0-Ag14
Target background: Anti-silencing function 1 (Asf1) belongs to the H3/H4 family of histone chaperones. Its function has not been fully elucidated but it is believed to be involved in ensuring a constant supply of histones at sites of nucleosome assembly. Asf1 interacts with the DNA damage checkpoint protein Rad53 and so may have a role in cell cycle regulation and DNA responses. ASF1 A and B (the two human subtypes) are the only known substrate for Tousled-like kinase (TLK). The Tousled kinases are themselves regulated by the checkpoint protein kinases involved in the DNA damage response.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Sillj et al. 2001. Curr Biol. 11(13):1068-73. PMID: 11470414.

Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.

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