Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker […]
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151261 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | IHC ; IP ; WB |
| Target: | Cyclin A |
| Reactivity: | Human |
| Clone: | AT10.2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146 |
|---|---|
| Product description: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. E23.1 is extremely sensitive for immunoblotting Cyclin A. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Recombinant Human Cyclin A |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358. Simian virus 40 large T antigen associates with cyclin A and p33cdk2. |
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