A mouse monoclonal antibody recognising CYP1A2, used to study cytochrome P450 expression, xenobiotic metabolism and drug-metabolising enzyme biology.
| Inventor | Institute |
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| Roland Wolf | Syngenta Crop |
| SKU: | 151201 |
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| Product description: | Anti-Cytochrome P450 1A2 [D15] is a mouse monoclonal antibody that recognises CYP1A2 in human, mouse and rat samples. It is used to detect and study cytochrome P450 1A2 expression, supporting research into xenobiotic metabolism, drug-metabolising enzyme biology and tissue-specific metabolic activity. Reported applications include ELISA, immunohistochemistry, immunofluorescence and western blot. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Molecular weight: | 52 kDa |
| Immunogen: | MC1a (Preparation C31B4, rat liver cytochrome P4501A2) |
| Cat. #: | 151201 |
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| Provenance and Ownership: | The Anti-Cytochrome P450 1A2 [D15] is owned by Cancer Research UK. CancerTools supplies the Anti-Cytochrome P450 1A2 [D15] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Cytochrome P450 1A2 [D15] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | ELISA ; IHC ; IF ; WB |
| Target: | Cytochrome P450 1A2, CYP1A2 |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | D15 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Getachew et al. 2010. Biochem Pharmacol. 79(9):1363-71. PMID: 20036646. Seibert et al. 2009. J Proteome Res. 8(4):1672-81. PMID: 19714871. Lane et al. 2007. Mol Cell Proteomics. 6(6):953-62. PMID: 17296599. |
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