Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting
| Inventor | Institute |
|---|---|
| John Kemshead | Institute of Child Health |
| SKU: | 151179 |
|---|---|
| Product description: | Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 220-240 kDa |
| Immunogen: | 16 week human foetal brain. |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151179 |
|---|---|
| Provenance and Ownership: | The Anti-L1CAM [UJ181.4] is owned by Cancer Research UK. CancerTools supplies the Anti-L1CAM [UJ181.4] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-L1CAM [UJ181.4] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction; Neurobiology |
| Application: | IHC ; IP ; WB |
| Target: | L1 cell adhesion molecule (L1CAM; CD171) |
| Reactivity: | Human |
| Clone: | UJ181.4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Garson.JA. 1983. MD Thesis. Birmingham Bourne et al. 1989. Hybridoma. 8(4):415-26. PMID: 2550359. Monoclonal antibodies M340 and UJ181.4 recognize antigens associated with primitive neuroectodermal tumours/tissues. Coakham et al. 1985. J Clin Pathol. 38(2):165-73. PMID: 3881481. Immunohistological diagnosis of central nervous system tumours using a monoclonal antibody panel. Kemshead et al. 1983. Int J Cancer. 31(2):187-95. PMID: 6826247. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells. |
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