Anti-p53 [Pab 1801]

PAb 1801 can be used for the specific detection of human p53 that is synthesised in the presence of p53 from other species.

Contributors

Inventor Institute
Lawrence Banks Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151144
Product description: PAb 1801 can be used for the specific detection of human p53 that is synthesised in the presence of p53 from other species.
Alternate name: Mouse monoclonal P53 antibody
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 53 kDa
Immunogen: Purified p53-b-galactosidase fusion proteins
Myeloma used: P3/NS1/1-Ag4.1
Cat. #: 151144
Provenance and Ownership: The Anti-p53 [Pab 1801] is owned by Cancer Research UK. CancerTools supplies the Anti-p53 [Pab 1801] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-p53 [Pab 1801] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Other
Research Fields: Apoptosis and autophagy; Cancer; Cell biology; Genetics
Application: ChIP ; ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
Target: p53
Reactivity: Human
Clone: Pab 1801
Host: Mouse
Class: Monoclonal
Primary citation: Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.
Target background: p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the “guardian of the genome,” p53 prevents gene mutations. Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of fun…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: ‘-15° C to -25° C
Shipping conditions: Dry ice
References:

Beckerman et al. 2016. Cell Cycle. :1-14. PMID: 27210019.

Loughery et al. 2014. Nucleic Acids Res. 42(12):7666-80. PMID: 24928858.

Thomas et al. 2013. J Biol Chem. 288(11):7606-17. PMID: 23341460.

Thomas et al. 2012. PLoS One. 7(5):e36447. PMID: 22590546.

Masters et al. 2003. J Pathol. 200(1):74-81. PMID: 12692844.

Wolff et al. 2001. Oncogene. 20(11):1307-17. PMID: 11313875.

Said et al. 1992. Am J Pathol. 141(6):1343-8. PMID: 1466398.

Porter et al. 1992.

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