A mouse monoclonal antibody recognising human integrin alpha 2b/CD41, used to study platelet biology, thrombus research and tumour cell binding.
| Inventor | Institute |
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| John Kemshead | Institute of Child Health |
| SKU: | 151128 |
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| Product description: | Anti-Integrin a2b [M148] mAb is a mouse monoclonal antibody that recognises human integrin alpha 2b/CD41. It is used to study platelet aggregation, thrombus biology and tumour cell binding, with reported reactivity to some medulloblastoma, neuroblastoma, rhabdomyosarcoma and other solid tumour cells. Reported applications include FACS, immunohistochemistry, immunofluorescence, immunoprecipitation and functional assays. |
| Alternate name: | Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR |
| Additional notes: | No binding is observed to marrow constituents other than platelets and megakaryocytes. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 110-130 kDa |
| Immunogen: | Homogenized human medulloblastoma tissue. |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151128 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Cell signaling and signal transduction |
| Application: | FACS ; IHC ; IF ; IP ; Fn |
| Target: | Integrin alpha 2b (CD41) |
| Reactivity: | Human |
| Clone: | M148 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2b?3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic c… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646. Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896. Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261. |
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