Anti-cMyc [9E10]

Monoclonal antibody raised against sequence of c-Myc, a proto-oncogene heavily implicated in a variety of (hematopoietic) cancers, which has been used in cancer research to detect and understand the distribution of the c-Myc oncogene product.

Contributors

Inventor Institute
Gerard Evan University of California San Francisco
SKU: 151067
Product description: Monoclonal antibody raised against sequence of c-Myc, a proto-oncogene heavily implicated in a variety of (hematopoietic) cancers, which has been used in cancer research to detect and understand the distribution of the c-Myc oncogene product.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Synthetic peptide (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA – 32 aa) corresponding to 408-439 of Human c-Myc conjugated to KLH.
Immunogen Uniprot ID: P01106
Myeloma used: Sp2/0-Ag14
Cat. #: 151067
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Cervical cancer; Breast cancer; Lung cancer; Colorectal cancer
Research Fields: Cancer; Cell biology; Genetics; Stem cell biology
Application: ChIP ; ELISA ; IHC ; IP ; WB
Target: c Myc epitope tag
Reactivity: Human
Clone: 9A
Host: Mouse
Class: Monoclonal
Target background: Anti c-Myc is raised against the proto-oncogene c-Myc, analogous to the avian v-Myc gene a very strong proto-oncogene often found to be upregulated in cancer. Aberrant and constitutive expression of c-Myc has been particularly implicated in the upregulation of genes involved in cellular proliferation and has been identified in cancers including carcinoma of cervix, colon, breast, lung and stomach, plus a translocation leading to Burkitt’s lymphoma. The gene product of c-Myc (p62) is upregulat…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Si et al. 2018. Int J Biol Sci. 14(2):165-177. PMID: 29483835.

Oh et al. 2018. Cell Rep. 25(7):1681-1692.e4. PMID: 30428339.

Aldon et al. 2018. Cell Rep. 24(12):3324-3338.e5. PMID: 30232012.

Rodrguez-Escudero et al. 2018. Sci Rep. 8(1):7732. PMID: 29769614.

Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960.

Mammalian polymerase promotes alternative NHEJ and suppresses recombination.

Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842.

The diab…

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