P3-11F Monoclonal Antibody
Contributors
| Inventor | Institute |
|---|---|
| Bernhard Singer | Leukocom GmbH |
| Product description: | CEACAM is a glycoprotein involved in cell adhesion and intracellular signaling. It is normally produced during fetal development in the gut, and its production stops before birth. CEA is re-expressed in increased amounts in Intestinal Carcinomas and several other tumors. |
|---|---|
| Alternate name: | Anti human CEACAM5/6-deltaN (CD66e/CD66c) |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | Human CEACAM5: 77 kDa; Macaque CEACAM5: 77 kDa; Human CEACAM6: 37 kDa |
| Immunogen: | human CEACAM6 deltaN-huFc fusionprotein |
| Cat. #: | 162454 |
|---|---|
| Tool sub type: | Primary antibody |
| Research Fields: | Immunology |
| Application: | Flow Cytometry, ELISA, IHC, IP, WB |
| Target: | Binds specifically to human CEACAM5 and CEACAM6 (CD66a/c). |
| Reactivity: | Human |
| Clone: | P3-11F |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Zi-Wen Han et al. (2020) Investigational New Drug 38(6):1888-1898. |
| Storage buffer: | PBS with 0.02% azide |
|---|---|
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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162454 Immunofluorescence Analysis
10 μg/ml of mAb P3-11F was used to stain paraffin fixed normal human colon tissue, followed by detection with biotinylated anti mouse antibody and Streptavidin-Cy3 (positive staining in red). Nuclei were
counterstained by DAPI (blue). Line of staining shows CEACAM5/6 expression, which
appears at the outer layer of inner epithelial cells.
