CHEC-9 immunomodulatory Peptide

The CHEC-9 (peptide sequence CHEASAAQC) sequence is a fragment of a human diffusible survival evasion peptide (DSEP). CHEC-9 is an anti-inflammatory/neuroprotective peptide that uncompetitively binds and inhibit secreted phospholipase A2 (sPLA2). Allowing for the study of PLA2-directed inflammation of traumatic and autoimmune (Autoimmune Myeloencephalitis) neurodegenerative disorders. CHEC-9 also binds HSP70 and may influence HSP70-dependent dissolution […]

Contributors

Inventor Institute
Timothy Cunningham Drexel University
Cat. #: 154133
Research Fields: Immunology;Neurobiology
Alternate name: Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP)
Product description: The CHEC-9 (peptide sequence CHEASAAQC) sequence is a fragment of a human diffusible survival evasion peptide (DSEP). CHEC-9 is an anti-inflammatory/neuroprotective peptide that uncompetitively binds and inhibit secreted phospholipase A2 (sPLA2). Allowing for the study of PLA2-directed inflammation of traumatic and autoimmune (Autoimmune Myeloencephalitis) neurodegenerative disorders. CHEC-9 also binds HSP70 and may influence HSP70-dependent dissolution of protein aggregates that accumulate in aging and disease models like Parkinson’s and Alzheimer’s Disease.
References:

Cunningham et al. 2015. Rejuvenation Res. 18(2):136-44. PMID: 25485461.

Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related disease.

Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition.

Chen et al. 2012. PLoS One. 7(6):e39257. PMID: 22720084.

Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis

Cunningham et al. 2006. J Neuroinflammation. 3:25. PMID: 16965626.

Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9.

Cunningham et al. 2004. J Neurotrauma. 21(11):1683-91. PMID: 15684658.

Systemic treatment of cerebral cortex lesions in rats with a new secreted phospholipase A2 inhibitor.

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