Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex.
| Inventor | Institute |
|---|---|
| Dawn Batty ; Rick Wood | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 152161 |
|---|---|
| Product description: | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. |
| Conjugation: | Unconjugated |
| Immunogen: | 96-299 of human XPC protein |
| Cat. #: | 152161 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; IF ; WB |
| Target: | Xeroderma Pigmentosum Group C (XPC) |
| Reactivity: | Human |
| Clone: | RW028 |
| Host: | Rabbit |
| Class: | Polyclonal |
| Target background: | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome. O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410. O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410. Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504. Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks. Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551. Atypical protein kinase C stimulates nucleotide excision repair activity. Arajo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578. Strong Fn interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. Kberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455. Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours. |
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