Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
| Inventor | Institute |
|---|---|
| Tyson Sharp | University College London (UCL) |
| SKU: | 151610 |
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| Product description: | Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 50 kDa (full) to 17 kDa |
| Immunogen: | Recombinant protein |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151610 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy; Biochemistry; Microbiology |
| Application: | ELISA ; IF ; IP ; WB |
| Target: | K15 (putative integral transmembrane protein similar to LMP2A) |
| Reactivity: | Human ; Virus |
| Clone: | 3B5/D7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities. |
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| Format: | Liquid |
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| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170. K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. |
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