TNFRSF18 is a type I transmembrane protein with homology to members of divergent costimulatory molecules in the TNFRSF.
| Inventor | Institute |
|---|---|
| Ayham Alnabulsi | Vertebrate Antibodies Limited |
| SKU: | 152606 |
|---|---|
| Product description: | TNFRSF18 is a type I transmembrane protein with homology to members of divergent costimulatory molecules in the TNFRSF. To date three isoforms of TNFRSF18 have been identified, including one soluble form that lacks a transmembrane domain. According to homology of the cytoplasmic domain, TNFRSF18 and other three TNFRSF members (4ÄËĂÂĂÂ1BB, CD27, and OX40) probably constitute a new subfamily as divergent costimulators. TNFRSF18 and the other subfamily members bind TRAF molecules and activate NF-KB. |
| Alternate name: | Tumor Necrosis Factor Receptor Superfamily Member 18; Glucocorticoid-Induced TNFR-Related Protein; Activation-Inducible TNFR Family Receptor; AITR; GITR; TNF Receptor Superfamily Activation-Inducible Protein; CD357 Antigen; GITR-D; CD357 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 26 kDa |
| Immunogen: | Ovalbumin conjugated peptide – PWQQKWVQE |
| Cat. #: | 152606 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology |
| Application: | ELISA ; IHC ; WB |
| Target: | Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18-soluble form), GITR |
| Reactivity: | Human |
| Clone: | T10P2H9*B9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | TNFRSF18 is a type I transmembrane protein with homology to members of divergent costimulatory molecules in the TNFRSF. To date three isoforms of TNFRSF18 have been identified, including one soluble form that lacks a transmembrane domain. According to homology of the cytoplasmic domain, TNFRSF18 and other three TNFRSF members (41BB, CD27, and OX40) probably constitute a new subfamily as divergent costimulators. TNFRSF18 and the other subfamily members bind TRAF molecules and activate NF-KB. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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